This study investigated the possibility of acquired hypermetropic anisometropia development in young children after treating them for anisometropic amblyopia. Study subjects were 87 patients aged <6 years at their initial visit to Yoda Eye Clinic who could be followed up for ≥3 years. Patients in whom the difference in corneal curvature diameter was ≥0.1 mm were excluded. Treatment involved fitting spectacles, administering atropine eye drops to the dominant eye, and occlusion of the dominant eye. This resulted in a 46% correction of anisometropia, indicating differences in response to treatment, with reversibility depending on the duration of anisometropia. Anisometropia almost completely disappeared in three patients who were administered Mydrin-P(tropicamide) eye drops at the initial visit. In 13 patients, Mydrin-P eye drops administered at the initial visit resulted in no change. However, it decreased the requirement of atropine refraction when remission had been achieved by adjusting the dominant eye with atropine treatment and regularly using spectacles. In 24 patients, long-term follow-up revealed that adjusting the ability of the amblyopic eye to recovery resulted in a reduction of anisometropia. These results suggested that if treatment is initiated immediately after the onset of anisohypermetropic amblyopia, anisometropia can be reduced or eliminated.
YODA EYE CLINIC Director Hatsue Yoda